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Chemoselective Oxidative C(CO)[BOND]C(methyl) Bond Cleavage of Methyl Ketones to Aldehydes Catalyzed by CuI with Molecular Oxygen


  • This work was supported by the NNSFC (21172029, 21202016, and 31101010) and the FRFCU (11CXPY005).


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Aldehyde Termination: A novel copper-catalyzed transformation from methyl ketones into aldehydes has been accomplished. This method is applicable to a wide range of aromatic and aliphatic methyl ketones and chemoselectively produces aldehydes, accompanied by the release of hydrogen (H2) and carbon dioxide (CO2) as by-products.