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Keywords:

  • anthracyclines;
  • antitumor agents;
  • MDR;
  • metagenomics;
  • natural products
Thumbnail image of graphical abstract

Sequence-tag-guided screening of soil environmental DNA libraries can be used to guide the discovery of new compounds with improved properties. In heterologous expression experiments the eDNA-derived arm cluster encodes arimetamycin A (see picture), an anthracycline that is more potent than clinically used natural anthracyclines and retains activity against multidrug-resistant (MDR) cancer cells.