This work was supported by NIH GM077516. S.F.B. is an HHMI Early Career Scientist. We thank Dr. José A. Salas for the generous gift of pRham.
Arimetamycin A: Improving Clinically Relevant Families of Natural Products through Sequence-Guided Screening of Soil Metagenomes†
Article first published online: 3 SEP 2013
Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 52, Issue 42, pages 11063–11067, October 11, 2013
How to Cite
Kang, H.-S. and Brady, S. F. (2013), Arimetamycin A: Improving Clinically Relevant Families of Natural Products through Sequence-Guided Screening of Soil Metagenomes. Angew. Chem. Int. Ed., 52: 11063–11067. doi: 10.1002/anie.201305109
- Issue published online: 10 OCT 2013
- Article first published online: 3 SEP 2013
- Manuscript Received: 13 JUN 2013
- NIH. Grant Number: GM077516
- antitumor agents;
- natural products
Sequence-tag-guided screening of soil environmental DNA libraries can be used to guide the discovery of new compounds with improved properties. In heterologous expression experiments the eDNA-derived arm cluster encodes arimetamycin A (see picture), an anthracycline that is more potent than clinically used natural anthracyclines and retains activity against multidrug-resistant (MDR) cancer cells.