Arimetamycin A: Improving Clinically Relevant Families of Natural Products through Sequence-Guided Screening of Soil Metagenomes

Authors


  • This work was supported by NIH GM077516. S.F.B. is an HHMI Early Career Scientist. We thank Dr. José A. Salas for the generous gift of pRham.

Abstract

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Sequence-tag-guided screening of soil environmental DNA libraries can be used to guide the discovery of new compounds with improved properties. In heterologous expression experiments the eDNA-derived arm cluster encodes arimetamycin A (see picture), an anthracycline that is more potent than clinically used natural anthracyclines and retains activity against multidrug-resistant (MDR) cancer cells.

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