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Cobalt-Catalyzed Intramolecular Olefin Hydroarylation Leading to Dihydropyrroloindoles and Tetrahydropyridoindoles


  • This work was supported by the National Research Foundation Singapore (NRF-RF2009-05), Nanyang Technological University, and JST, CREST. We thank Dr. Yongxin Li and Dr. Rakesh Ganguly (Nanyang Technological University) for assistance in X-ray diffraction analysis.


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Regiodivergent catalysis: Cobalt N-heterocyclic carbene (NHC) catalysts promote intramolecular olefin hydroarylation of indoles bearing an N-homoallyl or bis(homoallyl) tether and a C3 aldimine directing group to afford dihydropyrroloindoles and tetrahydropyridoindoles under mild conditions. The course of the cyclization is dependent on the tether, but can be controlled by the NHC ligand.