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Keywords:

  • alkynes;
  • bioorganometallic chemistry;
  • photochemistry;
  • thermochemistry;
  • vitamin B12
Thumbnail image of graphical abstract

Don't take this antivitamin! 2-Phenylethynylcobalamin (see picture) was prepared in a newly developed radical reaction using cob(II)alamin and 1-iodo-2-phenylethyne. It has an exceptionally short organometallic bond and is a remarkably light-stable and heat-resistant organometallic cobalamin. It is bound well by two important proteins of the human B12 transport system and has properties that are as expected for a new type of an “antivitamin B12”.