We thank T. Müller for mass spectra.
Phenylethynylcobalamin: A Light-Stable and Thermolysis-Resistant Organometallic Vitamin B12 Derivative Prepared by Radical Synthesis†
Article first published online: 12 SEP 2013
Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 52, Issue 43, pages 11406–11409, October 18, 2013
How to Cite
Ruetz, M., Salchner, R., Wurst, K., Fedosov, S. and Kräutler, B. (2013), Phenylethynylcobalamin: A Light-Stable and Thermolysis-Resistant Organometallic Vitamin B12 Derivative Prepared by Radical Synthesis. Angew. Chem. Int. Ed., 52: 11406–11409. doi: 10.1002/anie.201305206
- Issue published online: 14 OCT 2013
- Article first published online: 12 SEP 2013
- Manuscript Received: 17 JUN 2013
- bioorganometallic chemistry;
- vitamin B12
Don't take this antivitamin! 2-Phenylethynylcobalamin (see picture) was prepared in a newly developed radical reaction using cob(II)alamin and 1-iodo-2-phenylethyne. It has an exceptionally short organometallic bond and is a remarkably light-stable and heat-resistant organometallic cobalamin. It is bound well by two important proteins of the human B12 transport system and has properties that are as expected for a new type of an “antivitamin B12”.