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Elucidating the Neurotoxicity of the Star Fruit

Authors

  • Prof. Dr. Norberto Garcia-Cairasco,

    Corresponding author
    1. Ribeirão Preto School of Medicine, University of São Paulo, Av. Bandeirantes 3900, 14049-900, Ribeirão Preto, SP (Brazil)
    • Norberto Garcia-Cairasco, Ribeirão Preto School of Medicine, University of São Paulo, Av. Bandeirantes 3900, 14049-900, Ribeirão Preto, SP (Brazil)===

      Norberto P. Lopes, NPPNS, School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Avenida do Café s/n, 14040-903, Ribeirão Preto—SP (Brazil)===

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  • Prof. Dr. Miguel Moyses-Neto,

    1. Ribeirão Preto School of Medicine, University of São Paulo, Av. Bandeirantes 3900, 14049-900, Ribeirão Preto, SP (Brazil)
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  • Flavio Del Vecchio,

    1. Ribeirão Preto School of Medicine, University of São Paulo, Av. Bandeirantes 3900, 14049-900, Ribeirão Preto, SP (Brazil)
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  • José A. C. Oliveira,

    1. Ribeirão Preto School of Medicine, University of São Paulo, Av. Bandeirantes 3900, 14049-900, Ribeirão Preto, SP (Brazil)
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  • Francisco L. dos Santos,

    1. Ribeirão Preto School of Medicine, University of São Paulo, Av. Bandeirantes 3900, 14049-900, Ribeirão Preto, SP (Brazil)
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  • Dr. Olagide W. Castro,

    1. Ribeirão Preto School of Medicine, University of São Paulo, Av. Bandeirantes 3900, 14049-900, Ribeirão Preto, SP (Brazil)
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  • Dr. Gabriel M. Arisi,

    1. Ribeirão Preto School of Medicine, University of São Paulo, Av. Bandeirantes 3900, 14049-900, Ribeirão Preto, SP (Brazil)
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  • Prof. Dr. Márcio Dantas,

    1. Ribeirão Preto School of Medicine, University of São Paulo, Av. Bandeirantes 3900, 14049-900, Ribeirão Preto, SP (Brazil)
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  • Dr. Ruither O. G. Carolino,

    1. Ribeirão Preto School of Medicine, University of São Paulo, Av. Bandeirantes 3900, 14049-900, Ribeirão Preto, SP (Brazil)
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  • Prof. Dr. Joaquim Coutinho-Netto,

    1. Ribeirão Preto School of Medicine, University of São Paulo, Av. Bandeirantes 3900, 14049-900, Ribeirão Preto, SP (Brazil)
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  • Dr. Andre L. A. Dagostin,

    1. Ribeirão Preto School of Medicine, University of São Paulo, Av. Bandeirantes 3900, 14049-900, Ribeirão Preto, SP (Brazil)
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  • Dr. Marcelo C. A. Rodrigues,

    1. Ribeirão Preto School of Medicine, University of São Paulo, Av. Bandeirantes 3900, 14049-900, Ribeirão Preto, SP (Brazil)
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  • Prof. Dr. Ricardo M. Leão,

    1. Ribeirão Preto School of Medicine, University of São Paulo, Av. Bandeirantes 3900, 14049-900, Ribeirão Preto, SP (Brazil)
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  • Dr. Samir A. P. Quintiliano,

    1. Instituto de Química, Universidade de São Paulo (Brazil)
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  • Prof. Dr. Luiz F. Silva Jr.,

    1. Instituto de Química, Universidade de São Paulo (Brazil)
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  • Prof. Dr. Leonardo Gobbo-Neto,

    1. NPPNS, School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Avenida do Café s/n, 14040-903, Ribeirão Preto—SP (Brazil)
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  • Prof. Dr. Norberto P. Lopes

    Corresponding author
    1. NPPNS, School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Avenida do Café s/n, 14040-903, Ribeirão Preto—SP (Brazil)
    • Norberto Garcia-Cairasco, Ribeirão Preto School of Medicine, University of São Paulo, Av. Bandeirantes 3900, 14049-900, Ribeirão Preto, SP (Brazil)===

      Norberto P. Lopes, NPPNS, School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Avenida do Café s/n, 14040-903, Ribeirão Preto—SP (Brazil)===

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  • These studies honor the memory of the late Prof. Dr. Joaquim Coutinho-Netto, and were supported by FAPESP (09/51812-0), FAPESP-Cinapce, CNPq, INCT-if, CAPES, and PRONEX.

Abstract

original image

Caramboxin: Patients suffering from chronic kidney disease are frequently intoxicated after ingesting star fruit. The main symptoms of this intoxication are named in the picture. Bioguided chemical procedures resulted in the discovery of caramboxin, which is a phenylalanine-like molecule that is responsible for intoxication. Functional experiments in vivo and in vitro point towards the glutamatergic ionotropic molecular actions of caramboxin, which explains its convulsant and neurodegenerative properties.

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