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Keywords:

  • C[BOND]H activation;
  • deuteration;
  • palladium;
  • phenylacetic acids;
  • weak coordination

Abstract

We disclose a protocol for the palladium-catalyzed ortho-selective C[BOND]H deuteration of arenes. Phenylacetic acids and benzoic acids are suitable substrates for this reaction. This reaction offers a catalytic route to ortho-deuterated phenylacetic acids and benzoic acids and demonstrates the sharp difference in reactivity of palladacycle intermediates held together by weak and strong coordination.