Get access

A Powerful Hydrogen-Bond-Donating Organocatalyst for the Enantioselective Intramolecular Oxa-Michael Reaction of α,β-Unsaturated Amides and Esters


  • We thank Ryuta Kuramoto for experimental support. We gratefully acknowledge a Grant-in-Aid for Scientific Research (Y.T.) on Innovative Areas “Advanced Molecular Transformations by Organocatalysts” from MEXT (Japan).


original image

Tuning the organocatalyst: An unprecedented enantioselective intramolecular oxa-Michael reaction of unactivated α,β-unsaturated amides and esters catalyzed by a powerful hydrogen-bond-donating organocatalyst has been developed. Furthermore, the products obtained from this reaction have been used for the straightforward asymmetric synthesis of several natural products and biologically important compounds.