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A Powerful Hydrogen-Bond-Donating Organocatalyst for the Enantioselective Intramolecular Oxa-Michael Reaction of α,β-Unsaturated Amides and Esters

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  • We thank Ryuta Kuramoto for experimental support. We gratefully acknowledge a Grant-in-Aid for Scientific Research (Y.T.) on Innovative Areas “Advanced Molecular Transformations by Organocatalysts” from MEXT (Japan).

Abstract

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Tuning the organocatalyst: An unprecedented enantioselective intramolecular oxa-Michael reaction of unactivated α,β-unsaturated amides and esters catalyzed by a powerful hydrogen-bond-donating organocatalyst has been developed. Furthermore, the products obtained from this reaction have been used for the straightforward asymmetric synthesis of several natural products and biologically important compounds.

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