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Keywords:

  • high-mass detection;
  • MALDI;
  • mass spectrometry;
  • microchannel plate;
  • proteins
Thumbnail image of graphical abstract

Flying high: Application of an active pixel detector with high charge sensitivity to a linear time-of-flight mass spectrometer results in enhanced detection of high-mass proteins (such as Immunoglobulin G; IgG) using a conventional microchannel plate detection system. This technique thus provides a means to extend the mass range of such detectors as well as allowing direct visualization of mass-dependent ion-focusing phenomena (see picture).