Part of this research is supported by the Dutch Technology Foundation (STW), which is the Applied Science Division of the Nederlandse organisatie voor Wetenschappelijk Onderzoek (NWO); and the Technology Program of the Ministry of Economic Affairs, Project OTP 11956. This work is part of the research program of the Stichting voor Fundamenteel Onderzoek der Materie (FOM), which is financially supported by the NWO. We are grateful to Ronald Buijs for support for electronics and Gert Eijkel for development of data analysis software.
Enhanced Detection of High-Mass Proteins by Using an Active Pixel Detector†
Article first published online: 3 SEP 2013
Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 52, Issue 43, pages 11261–11264, October 18, 2013
How to Cite
Ellis, S. R., Jungmann, J. H., Smith, D. F., Soltwisch, J. and Heeren, R. M. A. (2013), Enhanced Detection of High-Mass Proteins by Using an Active Pixel Detector. Angew. Chem. Int. Ed., 52: 11261–11264. doi: 10.1002/anie.201305501
- Issue published online: 14 OCT 2013
- Article first published online: 3 SEP 2013
- Manuscript Received: 26 JUN 2013
- Nederlandse organisatie voor Wetenschappelijk Onderzoek
- high-mass detection;
- mass spectrometry;
- microchannel plate;
Flying high: Application of an active pixel detector with high charge sensitivity to a linear time-of-flight mass spectrometer results in enhanced detection of high-mass proteins (such as Immunoglobulin G; IgG) using a conventional microchannel plate detection system. This technique thus provides a means to extend the mass range of such detectors as well as allowing direct visualization of mass-dependent ion-focusing phenomena (see picture).