We thank the NIH (CA140173) for financial support.
Lipid Pools As Photolabile “Protecting Groups”: Design of Light-Activatable Bioagents†
Article first published online: 31 JUL 2013
Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 52, Issue 38, pages 9936–9939, September 16, 2013
How to Cite
Nguyen, L. T., Oien, N. P., Allbritton, N. L. and Lawrence, D. S. (2013), Lipid Pools As Photolabile “Protecting Groups”: Design of Light-Activatable Bioagents . Angew. Chem. Int. Ed., 52: 9936–9939. doi: 10.1002/anie.201305510
- Issue published online: 12 SEP 2013
- Article first published online: 31 JUL 2013
- Manuscript Received: 26 JUN 2013
- NIH. Grant Number: CA140173
- cell adhesion;
- fluorescent probes;
Inactive in the membrane: Lipidated light-responsive constructs that sequester bioagents (R, see scheme) to the membranes of organelles and cells have been constructed. When membrane-bound, the bioagent is not susceptible to processing by its biological target. Photolysis releases the bioagent from its membrane anchor and thereby renders it biologically active.