Lipid Pools As Photolabile “Protecting Groups”: Design of Light-Activatable Bioagents

Authors

  • Luong T. Nguyen,

    1. Department of Biomedical Engineering, Department of Chemistry, Division of Chemical Biology and Medicinal Chemistry, and the Department of Pharmacology, University of North Carolina, Chapel Hill, NC 27599 (USA)
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  • Nathan P. Oien,

    1. Department of Biomedical Engineering, Department of Chemistry, Division of Chemical Biology and Medicinal Chemistry, and the Department of Pharmacology, University of North Carolina, Chapel Hill, NC 27599 (USA)
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  • Prof. Nancy L. Allbritton,

    1. Department of Biomedical Engineering, Department of Chemistry, Division of Chemical Biology and Medicinal Chemistry, and the Department of Pharmacology, University of North Carolina, Chapel Hill, NC 27599 (USA)
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  • Prof. David S. Lawrence

    Corresponding author
    1. Department of Biomedical Engineering, Department of Chemistry, Division of Chemical Biology and Medicinal Chemistry, and the Department of Pharmacology, University of North Carolina, Chapel Hill, NC 27599 (USA)
    • Department of Biomedical Engineering, Department of Chemistry, Division of Chemical Biology and Medicinal Chemistry, and the Department of Pharmacology, University of North Carolina, Chapel Hill, NC 27599 (USA)===

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  • We thank the NIH (CA140173) for financial support.

Abstract

original image

Inactive in the membrane: Lipidated light-responsive constructs that sequester bioagents (R, see scheme) to the membranes of organelles and cells have been constructed. When membrane-bound, the bioagent is not susceptible to processing by its biological target. Photolysis releases the bioagent from its membrane anchor and thereby renders it biologically active.

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