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Keywords:

  • antibiotics;
  • natural products;
  • structural revision;
  • tetracyclines;
  • total synthesis
Thumbnail image of graphical abstract

The potent and complex antibiotic viridicatumtoxin B is a member of the tetracycline family and exhibits impressive activity against a variety of Gram-positive bacterial strains, including methicillin-resistant Staphylococcus aureus (MRSA) and Enterococcus faecalis (shown in the background). In their Communication on page 8736 ff.,, K. C. Nicolaou et al. describe the total synthesis and structural revision of viridicatumtoxin B, thus paving the way for future molecular design, chemical syntheses, and biological investigations.