These authors contributed equally to this work.
Cover Picture: Total Synthesis and Structural Revision of Viridicatumtoxin B (Angew. Chem. Int. Ed. 33/2013)
Article first published online: 23 JUL 2013
Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 52, Issue 33, page 8475, August 12, 2013
How to Cite
Nicolaou, K. C., Nilewski, C., Hale, C. R. H., Ioannidou, H. A., ElMarrouni, A. and Koch, L. G. (2013), Cover Picture: Total Synthesis and Structural Revision of Viridicatumtoxin B (Angew. Chem. Int. Ed. 33/2013). Angew. Chem. Int. Ed., 52: 8475. doi: 10.1002/anie.201305680
- Issue published online: 8 AUG 2013
- Article first published online: 23 JUL 2013
- natural products;
- structural revision;
- total synthesis
The potent and complex antibiotic viridicatumtoxin B is a member of the tetracycline family and exhibits impressive activity against a variety of Gram-positive bacterial strains, including methicillin-resistant Staphylococcus aureus (MRSA) and Enterococcus faecalis (shown in the background). In their Communication on page 8736 ff.,, K. C. Nicolaou et al. describe the total synthesis and structural revision of viridicatumtoxin B, thus paving the way for future molecular design, chemical syntheses, and biological investigations.