Cover Picture: Total Synthesis and Structural Revision of Viridicatumtoxin B (Angew. Chem. Int. Ed. 33/2013)

Authors

  • Prof. Dr.  K. C. Nicolaou,

    Corresponding author
    1. Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037 (USA)
    2. Department of Chemistry and Biochemistry, University of California, San Diego 9500 Gilman Drive, La Jolla, CA 92093 (USA)
    3. Department of Chemistry, BioScience Research Collaborative, Rice University, 6100 Main Street, Houston, TX 77005 (USA)
    • Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037 (USA)
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  • Dr. Christian Nilewski,

    1. Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037 (USA)
    2. Department of Chemistry and Biochemistry, University of California, San Diego 9500 Gilman Drive, La Jolla, CA 92093 (USA)
    3. Department of Chemistry, BioScience Research Collaborative, Rice University, 6100 Main Street, Houston, TX 77005 (USA)
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    • These authors contributed equally to this work.

  • Christopher R. H. Hale,

    1. Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037 (USA)
    2. Department of Chemistry and Biochemistry, University of California, San Diego 9500 Gilman Drive, La Jolla, CA 92093 (USA)
    3. Department of Chemistry, BioScience Research Collaborative, Rice University, 6100 Main Street, Houston, TX 77005 (USA)
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    • These authors contributed equally to this work.

  • Dr. Heraklidia A. Ioannidou,

    1. Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037 (USA)
    2. Department of Chemistry and Biochemistry, University of California, San Diego 9500 Gilman Drive, La Jolla, CA 92093 (USA)
    3. Department of Chemistry, BioScience Research Collaborative, Rice University, 6100 Main Street, Houston, TX 77005 (USA)
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  • Dr. Abdelatif ElMarrouni,

    1. Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037 (USA)
    2. Department of Chemistry and Biochemistry, University of California, San Diego 9500 Gilman Drive, La Jolla, CA 92093 (USA)
    3. Department of Chemistry, BioScience Research Collaborative, Rice University, 6100 Main Street, Houston, TX 77005 (USA)
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  • Lizanne G. Koch

    1. Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037 (USA)
    2. Department of Chemistry and Biochemistry, University of California, San Diego 9500 Gilman Drive, La Jolla, CA 92093 (USA)
    3. Department of Chemistry, BioScience Research Collaborative, Rice University, 6100 Main Street, Houston, TX 77005 (USA)
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Abstract

original image

The potent and complex antibiotic viridicatumtoxin B is a member of the tetracycline family and exhibits impressive activity against a variety of Gram-positive bacterial strains, including methicillin-resistant Staphylococcus aureus (MRSA) and Enterococcus faecalis (shown in the background). In their Communication on page 8736 ff.,, K. C. Nicolaou et al. describe the total synthesis and structural revision of viridicatumtoxin B, thus paving the way for future molecular design, chemical syntheses, and biological investigations.

Cartoon 1.

The potent and complex antibiotic viridicatumtoxin B is a member of the tetracycline family and exhibits impressive activity against a variety of Gram-positive bacterial strains, including methicillin-resistant Staphylococcus aureus (MRSA) and Enterococcus faecalis (shown in the background). In their Communication on page 8736 ff.,, K. C. Nicolaou et al. describe the total synthesis and structural revision of viridicatumtoxin B, thus paving the way for future molecular design, chemical syntheses, and biological investigations.

Electrocatalysis

In their Communication on page 8546 ff., S. H. Yu et al. report a Ni/NiO/CoSe2 catalyst that is currently the best Pt-free electrocatalyst for the hydrogen evolution reaction in acidic medium.

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Room-Temperature Ice

Nano-sized graphene oxide flakes on graphite induce room-temperature ice growth on the substrate. In their Communication on page 8708 ff., K. P. Loh et al. show that crystal nucleation and growth can be studied in real time.

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Hollow Nanostructures

X. W. Lou, Y. Xie, et al. describe in their Communication on page 8579 ff. the fabrication of complex hollow tube-in-tube nanostructures, which are promising materials for electrocatalysts and electrodes.

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Ancillary