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A “Dial-A-Receptor” Dynamic Combinatorial Library


  • We thank the EPSRC, COST (CM0703 and CM1005), Marie Curie RTN DCC, the ERC, and The Netherlands Organization for Scientific Research (NWO Rubicon to V.S.).


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Making receptors to order: A small dynamic combinatorial library (DCL), formed from two dithiols in water, provides a continuous range of six receptors of different sizes. The majority of the 30 tested amines and ammonium ions amplified receptors from this library, thus spanning the complete receptor-size range and showing that this DCL provides a generic platform for the development of receptors for this important class of compounds.