• Open Access

Lipid-Bilayer-Spanning DNA Nanopores with a Bifunctional Porphyrin Anchor


  • Funded by the Leverhulme Trust (RPG-170), UCL Chemistry, the EPSRC (Institutional Sponsorship Award), and the NPL. K.G. and U.F.K. acknowledge funding from his ERC starting grant. V.V.T. acknowledges funding from the Cambridge Commonwealth Trust, the Jawaharlal Nehru Memorial Trust, and the Emmy Noether program of the Deutsche Forschungsgemeinschaft. We thank Silvia Hernández-Ainsa for assistance in acquiring DLS data and Hugh Martin for preparing the ToC graphic.


original image

Holding tight: An artificial membrane nanopore assembled from DNA oligonucleotides carries porphyrin tags (red), which anchor the nanostructure into the lipid bilayer. The porphyrin moieties also act as fluorescent dyes to aid the microscopic visualization of the DNA nanopore.