Synthesis of Trisubstituted Alkenylstannanes through Copper-Catalyzed Three-Component Coupling of Alkylboranes, Alkynoates, and Tributyltin Methoxide


  • This work was supported by Grants-in-Aid for Young Scientists (A) and Challenging Exploratory Research, JSPS, to H.O. and by CREST and ACT-C, JST, to M.S. K.N. thanks the JSPS for their scholarship support.


original image

A versatile route to trisubstituted alkenylstannanes is presented. The alkyl and Sn moieties were introduced at the β and α carbon atoms of alkynoates, respectively, in a formal syn addition mode with complete regioselectivity (see scheme). A variety of functional groups were tolerated in the alkylboranes and alkynoates.