Generous support from the Max-Planck-Society and the Fonds der Chemischen Industrie is gratefully acknowledged. We also thank the members of our HPLC and GC departments for their support.
The Catalytic Asymmetric α-Benzylation of Aldehydes†
Article first published online: 24 NOV 2013
Copyright © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 53, Issue 1, pages 282–285, January 3, 2014
How to Cite
List, B., Čorić, I., Grygorenko, O. O., Kaib, P. S. J., Komarov, I., Lee, A., Leutzsch, M., Chandra Pan, S., Tymtsunik, A. V. and van Gemmeren, M. (2014), The Catalytic Asymmetric α-Benzylation of Aldehydes. Angew. Chem. Int. Ed., 53: 282–285. doi: 10.1002/anie.201306037
- Issue published online: 23 DEC 2013
- Article first published online: 24 NOV 2013
- Manuscript Received: 11 JUL 2013
- Fonds der Chemischen Industrie
- α-branched aldehydes;
- enamine catalysis;
The first aminocatalyzed α-alkylation of α-branched aldehydes with benzyl bromides as alkylating agents has been developed. Using a sterically demanding proline derived catalyst, racemic α-branched aldehydes are reacted with alkylating agents in a DYKAT process to give the corresponding α-alkylated aldehydes with quaternary stereogenic centers in good yields and high enantioselectivities.