The Catalytic Asymmetric α-Benzylation of Aldehydes

Authors


  • Generous support from the Max-Planck-Society and the Fonds der Chemischen Industrie is gratefully acknowledged. We also thank the members of our HPLC and GC departments for their support.

Abstract

The first aminocatalyzed α-alkylation of α-branched aldehydes with benzyl bromides as alkylating agents has been developed. Using a sterically demanding proline derived catalyst, racemic α-branched aldehydes are reacted with alkylating agents in a DYKAT process to give the corresponding α-alkylated aldehydes with quaternary stereogenic centers in good yields and high enantioselectivities.

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