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Keywords:

  • α-alkylation;
  • α-branched aldehydes;
  • DYKATt;
  • enamine catalysis;
  • organocatalysis

Abstract

The first aminocatalyzed α-alkylation of α-branched aldehydes with benzyl bromides as alkylating agents has been developed. Using a sterically demanding proline derived catalyst, racemic α-branched aldehydes are reacted with alkylating agents in a DYKAT process to give the corresponding α-alkylated aldehydes with quaternary stereogenic centers in good yields and high enantioselectivities.