Tissue Clearing for Optical Anatomy

Authors

  • Dr. Dmytro A. Yushchenko,

    1. Cell Biology & Biophysics Unit, European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg (Germany)
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  • Priv.-Doz. Dr. Carsten Schultz

    Corresponding author
    1. Cell Biology & Biophysics Unit, European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg (Germany)
    • Cell Biology & Biophysics Unit, European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg (Germany)

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  • Work in the Schultz lab is funded by the EMBL, the DFG (Transregio 83, SPP1623), the Helmholtz Association (LungSysII), the German Lung Research Center, and the EU (Integrated Project LIVIMODE, ITN Sphingonet). We thank Dr. Lars Hufnagel for discussions and critical reading of the manuscript.

Abstract

original image

Quest for transparency: Detailed optical imaging of complex biological entities remains an unmet goal mainly because of the light scattering of biological tissue. A new approach to tissue clearing termed CLARITY is getting us closer to an anatomical view of thick tissues and entire organs with cellular resolution.

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