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Indole Synthesis by Rhodium(III)-Catalyzed Hydrazine-Directed C[BOND]H Activation: Redox-Neutral and Traceless by N[BOND]N Bond Cleavage

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  • This work was supported by the European Research Council under auspices of the European Community’s Seventh Framework Program (FP7 2007–2013/ERC, grant agreement no. 25936), the Alexander von Humboldt Foundation (D.Z. and Z.S.), and the DFG (Leibniz award). The research of F.G. has been supported by the Alfried Krupp Prize for Young University Teachers of the Alfried Krupp von Bohlen und Halbach Foundation.

Abstract

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Fishing for complements! There is an alternative to the useful Fischer indole synthesis. The new method utilizes the same retrosynthetic disconnection but is based on a RhIII-catalyzed directed C[BOND]H activation step and a successive coupling with alkynes.

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