Get access

Photoactivation of a Psoralen-Blocked Luciferase Gene by Blue Light


  • We thank the DFG (STA 1053/3-1), the Fonds der Chemischen Industrie, and the University of Tübingen for generous financial support.


original image

A single psoralen cross-link completely blocks expression of a gene. An aminopyrene derivative has been found that allows the efficient light-triggered activation of cross-linked genes by UV or blue light. This paves the way to apply such psoralen cross-links for the photocleavable protection of nucleic acids.