Palladium-Catalyzed Asymmetric Hydrogenation of α-Acyloxy-1-arylethanones


  • This work was partly supported by the National Nature Science Foundation of China (No. 21172143, 21172145 and 21232004), Science and Technology Commission of Shanghai Municipality (No. 09JC1407800), Nippon Chemical Industrial Co. Ltd, Shanghai Jiao Tong University (SJTU), and the Instrumental Analysis Center of SJTU. We thank Prof. Tsuneo Imamoto and Dr. Masashi Sugiya for helpful discussions.


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First hand: The first example of a palladium-catalyzed asymmetric hydrogenation of α-acyloxy ketones (1) was accomplished to give the hydrogenated products 2 with by far the highest catalytic efficiency in up to quantitative conversions and excellent enantioselectivities. The hydrogenated products could serve as important intermediates for the preparation of many drug candidates. TFE=2,2,2-trifluoroethanol.