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DNA vs. Mirror-Image DNA: A Universal Approach to Tune the Absolute Configuration in DNA-Based Asymmetric Catalysis

Authors

  • Dr. Jocelyn Wang,

    1. Laboratoire de Chimie Organique, ESPCI ParisTech, CNRS (UMR 7084), 10 rue Vauquelin, 75231 Paris Cedex 05 (France)
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  • Dr. Erica Benedetti,

    1. Laboratoire de Chimie Organique, ESPCI ParisTech, CNRS (UMR 7084), 10 rue Vauquelin, 75231 Paris Cedex 05 (France)
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  • Dr. Lucas Bethge,

    1. NOXXON Pharma AG, Max-Dohrn-Strasse 8–10, 10589 Berlin (Germany)
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  • Dr. Stefan Vonhoff,

    1. NOXXON Pharma AG, Max-Dohrn-Strasse 8–10, 10589 Berlin (Germany)
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  • Dr. Sven Klussmann,

    1. NOXXON Pharma AG, Max-Dohrn-Strasse 8–10, 10589 Berlin (Germany)
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  • Dr. Jean-Jacques Vasseur,

    1. Institut des Biomolécules Max Mousseron, UMR 5247 CNRS-Universités Montpellier 1 et 2, Place Eugène Bataillon, 34095 Montpellier (France)
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  • Prof. Dr. Janine Cossy,

    1. Laboratoire de Chimie Organique, ESPCI ParisTech, CNRS (UMR 7084), 10 rue Vauquelin, 75231 Paris Cedex 05 (France)
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  • Prof. Dr. Michael Smietana,

    Corresponding author
    1. Institut des Biomolécules Max Mousseron, UMR 5247 CNRS-Universités Montpellier 1 et 2, Place Eugène Bataillon, 34095 Montpellier (France)
    • Michael Smietana, Institut des Biomolécules Max Mousseron, UMR 5247 CNRS-Universités Montpellier 1 et 2, Place Eugène Bataillon, 34095 Montpellier (France)

      Stellios Arseniyadis, Laboratoire de Chimie Organique, ESPCI ParisTech, CNRS (UMR 7084), 10 rue Vauquelin, 75231 Paris Cedex 05 (France)

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  • Dr. Stellios Arseniyadis

    Corresponding author
    1. Laboratoire de Chimie Organique, ESPCI ParisTech, CNRS (UMR 7084), 10 rue Vauquelin, 75231 Paris Cedex 05 (France)
    • Michael Smietana, Institut des Biomolécules Max Mousseron, UMR 5247 CNRS-Universités Montpellier 1 et 2, Place Eugène Bataillon, 34095 Montpellier (France)

      Stellios Arseniyadis, Laboratoire de Chimie Organique, ESPCI ParisTech, CNRS (UMR 7084), 10 rue Vauquelin, 75231 Paris Cedex 05 (France)

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  • We gratefully thank the Agence Nationale de la Recherche for financial support (NCiS project; ANR-2010-JCJC-715-1).

Abstract

original image

Mirror mirror on the wall: By taking advantage of the unique structural features of L-DNA, the first examples of left-helical enantioselective induction in the field of DNA-based asymmetric catalysis were realized. Most importantly, this approach is the only one that allows a reliable and predictable access to both enantiomers for any given reaction.

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