We thank Prof. S. A. Macgregor and S. Kazandjian for discussions and preliminary computational studies. The ICIQ Foundation and The Spanish Government (Grant CTQ2011-25418) are acknowledged for support of this work.
The Critical Effect of the Countercation in the Direct Cupration of Fluoroform with [Cu(OR)2]−†
Article first published online: 13 SEP 2013
Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 52, Issue 44, pages 11637–11641, October 25, 2013
How to Cite
Konovalov, A. I., Benet-Buchholz, J., Martin, E. and Grushin, V. V. (2013), The Critical Effect of the Countercation in the Direct Cupration of Fluoroform with [Cu(OR)2]−. Angew. Chem. Int. Ed., 52: 11637–11641. doi: 10.1002/anie.201306272
- Issue published online: 21 OCT 2013
- Article first published online: 13 SEP 2013
- Manuscript Received: 18 JUL 2013
- ICIQ Foundation
- The Spanish Government. Grant Number: CTQ2011-25418
- CH activation;
Just a spectator or a key player? The alkali-metal counterion (K+) plays a remarkable key role in the recently discovered cupration reaction of fluoroform with dialkoxycuprates. A total of eight Lewis acid and Lewis base centers synergistically interacting with one another arrange in a stable transition state, providing a low-energy pathway for this unique transformation.