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Keywords:

  • C[BOND]H activation;
  • copper;
  • fluorine;
  • fluoroform;
  • trifluoromethylation
Thumbnail image of graphical abstract

Just a spectator or a key player? The alkali-metal counterion (K+) plays a remarkable key role in the recently discovered cupration reaction of fluoroform with dialkoxycuprates. A total of eight Lewis acid and Lewis base centers synergistically interacting with one another arrange in a stable transition state, providing a low-energy pathway for this unique transformation.