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The Critical Effect of the Countercation in the Direct Cupration of Fluoroform with [Cu(OR)2]


  • We thank Prof. S. A. Macgregor and S. Kazandjian for discussions and preliminary computational studies. The ICIQ Foundation and The Spanish Government (Grant CTQ2011-25418) are acknowledged for support of this work.


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Just a spectator or a key player? The alkali-metal counterion (K+) plays a remarkable key role in the recently discovered cupration reaction of fluoroform with dialkoxycuprates. A total of eight Lewis acid and Lewis base centers synergistically interacting with one another arrange in a stable transition state, providing a low-energy pathway for this unique transformation.

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