Catalytic Asymmetric 1,3-Dipolar Cycloaddition of Two Different Ylides: Facile Access to Chiral 1,2,4-Triazinane Frameworks


  • This work is supported by the 973 Program (2011CB808600), NSFC (21172176, 21372180), NCET-10-0649, IRT-1030, and the Fundamental Research Funds for the Central Universities.


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Ylides at a crossing: An unprecedented 1,3-dipolar cycloaddition (cross-cycloaddition) between two different ylides (see scheme) was realized by using the chiral CuI/tBu-Phosferrox complex as the catalyst under mild reaction conditions. This catalytic system provides an expeditious approach to the construction of highly functionalized 1,2,4-triazinane derivatives in good yields with excellent diastereoselectivities and enantioselectivities.