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Keywords:

  • asymmetric catalysis;
  • azomethine ylide;
  • copper;
  • cycloaddition;
  • heterocycles
Thumbnail image of graphical abstract

Ylides at a crossing: An unprecedented 1,3-dipolar cycloaddition (cross-cycloaddition) between two different ylides (see scheme) was realized by using the chiral CuI/tBu-Phosferrox complex as the catalyst under mild reaction conditions. This catalytic system provides an expeditious approach to the construction of highly functionalized 1,2,4-triazinane derivatives in good yields with excellent diastereoselectivities and enantioselectivities.