Inside Cover: Positron Emission Tomography Imaging of Drug-Induced Tumor Apoptosis with a Caspase-Triggered Nanoaggregation Probe (Angew. Chem. Int. Ed. 40/2013)

Authors

  • Dr. Bin Shen,

    1. Department of Radiology, Molecular Imaging Program at Stanford, Stanford University School of Medicine, Stanford, CA 94305-5484 (USA)
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    • These authors contributed equally to this work.

  • Dr. Jongho Jeon,

    1. Department of Radiology, Molecular Imaging Program at Stanford, Stanford University School of Medicine, Stanford, CA 94305-5484 (USA)
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    • These authors contributed equally to this work.

  • Dr. Mikael Palner,

    1. Department of Radiology, Molecular Imaging Program at Stanford, Stanford University School of Medicine, Stanford, CA 94305-5484 (USA)
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  • Dr. Deju Ye,

    1. Department of Radiology, Molecular Imaging Program at Stanford, Stanford University School of Medicine, Stanford, CA 94305-5484 (USA)
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  • Dr. Adam Shuhendler,

    1. Department of Radiology, Molecular Imaging Program at Stanford, Stanford University School of Medicine, Stanford, CA 94305-5484 (USA)
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  • Prof. Frederick T. Chin,

    Corresponding author
    1. Department of Radiology, Molecular Imaging Program at Stanford, Stanford University School of Medicine, Stanford, CA 94305-5484 (USA)
    • Department of Radiology, Molecular Imaging Program at Stanford, Stanford University School of Medicine, Stanford, CA 94305-5484 (USA)

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  • Prof. Jianghong Rao

    Corresponding author
    1. Department of Radiology, Molecular Imaging Program at Stanford, Stanford University School of Medicine, Stanford, CA 94305-5484 (USA)
    • Department of Radiology, Molecular Imaging Program at Stanford, Stanford University School of Medicine, Stanford, CA 94305-5484 (USA)

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Abstract

original image

The caspase-3 activity in doxorubicin-treated tumor xenografts is studied by positron emission tomography (PET) using a novel 18F-labeled caspase-3-sensitive nanoaggregation tracer. In their Communication on page 10511 ff., J. Rao, F. T. Chin, et al. show that the enzyme-activatable tracer improves the PET imaging of apoptotic tumors by intramolecular macrocyclization and in situ aggregation of the cyclized tracer upon caspase-3 activation. (Picture: Jim Strommer and Lydia-Marie Joubert.)

Cartoon 1.

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