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Covalently Coupled Immunostimulant Heterodimers

Authors

  • Dr. Rock J. Mancini,

    1. Department of Chemistry, University of California, Irvine, 3038A Frederick Reines Hall, Irvine, CA 92697-2025 (USA)
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  • Janine K. Tom,

    1. Department of Chemistry, University of California, Irvine, 3038A Frederick Reines Hall, Irvine, CA 92697-2025 (USA)
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  • Prof. Aaron P. Esser-Kahn

    Corresponding author
    1. Department of Chemistry, University of California, Irvine, 3038A Frederick Reines Hall, Irvine, CA 92697-2025 (USA)
    • Department of Chemistry, University of California, Irvine, 3038A Frederick Reines Hall, Irvine, CA 92697-2025 (USA)

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  • We thank the Cahalan, Tsai, and Guan laboratories for reagents and instrument use. J.K.T acknowledges the NSF (DGE-0808392) for a fellowship. We acknowledge UC-Irvine for startup funds and an NIH New Innovator Award (DP2 AI112194).

Abstract

We report increased stimulation of dendritic cells via heterodimers of immunostimulants formed at a discrete molecular distance. Many vaccines present spatially organized agonists to immune cell receptors. These receptors cluster suggesting that signaling is increased by spatial organization and receptor proximity, but this has not been directly tested for multiple, unique receptors. In this study we probe the spatial aspect of immune cell activation using heterodimers of two covalently attached immunostimulants.

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