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Keywords:

  • contact quenching;
  • fluorescent probes;
  • fluorophore binding aptamer;
  • RNA imaging;
  • SRB-2 aptamer
Thumbnail image of graphical abstract

Bind and shine: Sulforhodamine B was converted into a very efficient fluorescence turn-on probe exclusively by contact quenching. The fluorescence of the probe increases more than 100-fold upon binding to a sulforhodamine-binding RNA aptamer (SRB-2). The probe and the SRB-2 aptamer were used to monitor transcriptions in real-time and to image RNA in live bacteria.