Back Cover: Arimetamycin A: Improving Clinically Relevant Families of Natural Products through Sequence-Guided Screening of Soil Metagenomes (Angew. Chem. Int. Ed. 42/2013)



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Watch your step, there is new chemistry everywhere In their Communication on page 11063 ff., S. F. Brady and H.-S. Kang describe a potent new anthracycline discovered by soil-DNA mining methods. DNA extracted from Sonoran Desert soil (USA) was screened for gene clusters predicted to produce new natural products. The soil-DNA-derived arm cluster encodes arimetamycin A, an anthracycline that is active against multidrug-resistant cancer cells and more potent than natural anthracyclines currently used in cancer therapy.

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