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Directing-Group-Assisted Copper-Catalyzed Olefinic Trifluoromethylation of Electron-Deficient Alkenes

Authors

  • Chao Feng,

    1. Department of Chemistry, University of Science and Technology of China, Hefei, Anhui 230026 (P. R. China)
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  • Prof. Dr. Teck-Peng Loh

    Corresponding author
    1. Department of Chemistry, University of Science and Technology of China, Hefei, Anhui 230026 (P. R. China)
    2. Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, 637371 (Singapore)
    • Department of Chemistry, University of Science and Technology of China, Hefei, Anhui 230026 (P. R. China)

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  • We gratefully acknowledge the USTC Research Fund, the Nanyang Technological University, and the Singapore Ministry of Education Academic Research Fund (ETRP 1002 111, MOE2010-T2-2-067, and MOE 2011-T2-1-013) for the funding of this research. We also thank Dr. Y. X. Li for support with X-ray analyses.

Abstract

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Assistance provided: The directing group in the title reaction not only activates the substrates but also allows the stereospecific formation of cis-trifluoromethylated products. The reaction is operationally simple and tolerates a wide variety of functional groups, thus providing an efficient method for the stereoselective synthesis of β-CF3-functionalized acrylamide derivatives.

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