D.W.S. is grateful for the financial support from NSERC of Canada and the award of a Canada Research Chair. T.M. gratefully acknowledges the financial support of a Digital Specialty Chemicals Graduate Scholarship.
Frustrated Lewis Pair Catalyzed Hydroamination of Terminal Alkynes†
Article first published online: 2 OCT 2013
Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 52, Issue 47, pages 12418–12421, November 18, 2013
How to Cite
Mahdi, T. and Stephan, D. W. (2013), Frustrated Lewis Pair Catalyzed Hydroamination of Terminal Alkynes. Angew. Chem. Int. Ed., 52: 12418–12421. doi: 10.1002/anie.201307254
- Issue published online: 12 NOV 2013
- Article first published online: 2 OCT 2013
- Manuscript Received: 18 AUG 2013
- NSERC of Canada
- frustrated Lewis pairs;
Catalytic amounts of the Lewis acid B(C6F5)3 enable the hydroamination of terminal alkynes by aryl amines to the corresponding enamines. In accord with the results of stoichiometric reactions, the mechanism of this reaction involves a frustrated Lewis pair (FLP). The hydroamination can be followed by an FLP-catalyzed hydrogenation, resulting in a one-pot stepwise synthesis of amine derivatives.