An Iron/Amine-Catalyzed Cascade Process for the Enantioselective Functionalization of Allylic Alcohols

Authors


  • Financial support from the Centre National de la Recherche Scientifique (CNRS) and Aix-Marseille Université is gratefully acknowledged. The authors gratefully thank Marion Jean and Nicolas Vanthuyne (Aix-Marseille Université) for chiral-phase HPLC analysis of all compounds.

Abstract

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Three is a lucky number: An enantioselective transformation of allylic alcohols into β-chiral saturated alcohols has been developed by combining two distinct metal- and organocatalyzed catalytic cycles. This waste-free triple cascade process merges an iron-catalyzed borrowing-hydrogen step with an aminocatalyzed nucleophilic addition reaction.

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