Inside Cover: The Catalytically Active Copper-Amyloid-Beta State: Coordination Site Responsible for Reactive Oxygen Species Production (Angew. Chem. Int. Ed. 42/2013)

Authors

  • Laure-Estelle Cassagnes,

    1. Université de Toulouse; UPS; UMR 152 PHARMA-DEV, Université Toulouse 3, 31062 Toulouse Cedex 09 (France)
    2. Institut de Recherche pour le développement (IRD); UMR 152 PHARMA-DEV, 31062 Toulouse Cedex 09 (France)
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  • Vincent Hervé,

    1. Université de Toulouse; UPS; UMR 152 PHARMA-DEV, Université Toulouse 3, 31062 Toulouse Cedex 09 (France)
    2. Institut de Recherche pour le développement (IRD); UMR 152 PHARMA-DEV, 31062 Toulouse Cedex 09 (France)
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  • Prof.Dr. Françoise Nepveu,

    1. Université de Toulouse; UPS; UMR 152 PHARMA-DEV, Université Toulouse 3, 31062 Toulouse Cedex 09 (France)
    2. Institut de Recherche pour le développement (IRD); UMR 152 PHARMA-DEV, 31062 Toulouse Cedex 09 (France)
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  • Dr. Christelle Hureau,

    1. Université de Toulouse; UPS, INPT, 31077 Toulouse (France)
    2. LCC (Laboratoire de Chimie de Coordination), CNRS UPR 8241, 205, route de Narbonne (France)
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  • Prof.Dr. Peter Faller,

    Corresponding author
    1. Université de Toulouse; UPS, INPT, 31077 Toulouse (France)
    2. LCC (Laboratoire de Chimie de Coordination), CNRS UPR 8241, 205, route de Narbonne (France)
    • Peter Faller, Université de Toulouse; UPS, INPT, 31077 Toulouse (France)

      Fabrice Collin, Université de Toulouse; UPS; UMR 152 PHARMA-DEV, Université Toulouse 3, 31062 Toulouse Cedex 09 (France)

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  • Dr. Fabrice Collin

    Corresponding author
    1. Université de Toulouse; UPS; UMR 152 PHARMA-DEV, Université Toulouse 3, 31062 Toulouse Cedex 09 (France)
    2. Institut de Recherche pour le développement (IRD); UMR 152 PHARMA-DEV, 31062 Toulouse Cedex 09 (France)
    • Peter Faller, Université de Toulouse; UPS, INPT, 31077 Toulouse (France)

      Fabrice Collin, Université de Toulouse; UPS; UMR 152 PHARMA-DEV, Université Toulouse 3, 31062 Toulouse Cedex 09 (France)

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Abstract

original image

In Alzheimer's disease, the redox-active copper center bound to the amyloid-beta peptide is able to produce reactive oxygen species by way of a low-populated redox-competent state. Insights into the coordination sphere of this state are reported by P. Faller, F. Collin, and co-workers in their Communication on page 11110 ff. The copper atom is bound by the N-terminal aspartate and the histidine dyad, while the third histidine acts as a gate keeper.

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