Photosensitization of Singlet Oxygen and In Vivo Photodynamic Therapeutic Effects Mediated by PEGylated W18O49 Nanowires

Authors

  • Poliraju Kalluru,

    1. Department of Chemistry, Frontier Research Centre on Fundamental and Applied Sciences of Matters, National Tsing Hua University, Hsinchu, Taiwan (Republic of China)
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  • Dr. Raviraj Vankayala,

    1. Department of Chemistry, Frontier Research Centre on Fundamental and Applied Sciences of Matters, National Tsing Hua University, Hsinchu, Taiwan (Republic of China)
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  • Prof. Chi-Shiun Chiang,

    1. Department of Biomedical Engineering and Environmental, Sciences, National Tsing Hua University, Hsinchu, Taiwan (Republic of China)
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  • Prof. Kuo Chu Hwang

    Corresponding author
    1. Department of Chemistry, Frontier Research Centre on Fundamental and Applied Sciences of Matters, National Tsing Hua University, Hsinchu, Taiwan (Republic of China)
    • Department of Chemistry, Frontier Research Centre on Fundamental and Applied Sciences of Matters, National Tsing Hua University, Hsinchu, Taiwan (Republic of China)

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  • The authors are grateful for financial support from the Frontier Research Center on Fundamental and Applied Sciences of Matters, the National Tsing Hua University, and the National Science Council, Taiwan. PEG=poly(ethylene glycol).

Abstract

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Upon excitation with near-infrared light (980 nm), PEGylated W18O49 nanowires can sensitize the formation of singlet oxygen and thus reactive oxygen species (ROS). The resulting photodynamic therapy (PDT) effect can cause the destruction of tumors in the absence of organic photosensitizers. PEG=poly(ethylene glycol), PTT=photothermal therapy.

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