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Keywords:

  • amines;
  • bioconjugation;
  • iron;
  • oxidation;
  • proteins

Abstract

Using a small-molecule-based screen, ferricyanide was identified as a mild and efficient oxidant for the coupling of anilines and o-aminophenols on protein substrates. This reaction is compatible with thiols and 1,2-diols, allowing its use in the creation of complex bioconjugates for use in biotechnology and materials applications.