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Keywords:

  • C–H functionalization;
  • natural products;
  • nitrene insertion;
  • total synthesis;
  • welwitindolinone
Thumbnail image of graphical abstract

The total synthesis of N-methylwelwitindolinone D isonitrile (1) has been achieved in 17 steps from a readily available carvone derivative. The route features a double C–H functionalization event involving a keto oxindole substrate to introduce the tetrahydrofuran ring of the natural product.