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Keywords:

  • arylation;
  • boroxines;
  • oxazolones;
  • oxidative Heck coupling;
  • palladium
Thumbnail image of graphical abstract

A whale of a scale: The title oxidative Heck coupling proceeded with unusual β selectivity to generate a variety of branched substituted oxazolones (see scheme; Ts=p-toluenesulfonyl). The three-step synthesis from readily available starting materials with a simple palladium catalyst and inexpensive reagents could be carried out in a single reaction vessel or scaled up for the preparation of large amounts of these amino acid precursors.