We thank Prof. Shiaw-Guang Hu for technical support. We also thank the National Science Council of the Republic of China, Taiwan (Grant No. NSC 100-2113M-009-015-MY2) and the “Aim for the Top University” program of the National Chiao Tung University and Ministry of Education, Taiwan, R.O.C. for funding. We are also grateful to the National Center for High-performance Computing of Taiwan for computer time and facilities.
Intramolecular Interactions of a Phenyl/Perfluorophenyl Pair in the Formation of Supramolecular Nanofibers and Hydrogels†
Article first published online: 13 JAN 2014
Copyright © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 53, Issue 7, pages 1921–1927, February 10, 2014
How to Cite
Hsu, S.-M., Lin, Y.-C., Chang, J.-W., Liu, Y.-H. and Lin, H.-C. (2014), Intramolecular Interactions of a Phenyl/Perfluorophenyl Pair in the Formation of Supramolecular Nanofibers and Hydrogels. Angew. Chem. Int. Ed., 53: 1921–1927. doi: 10.1002/anie.201307500
- Issue published online: 6 FEB 2014
- Article first published online: 13 JAN 2014
- Manuscript Revised: 17 OCT 2013
- Manuscript Received: 26 AUG 2013
- National Science Council of the Republic of China, Taiwan. Grant Number: NSC 100-2113M-009-015-MY2
- National Chiao Tung University
- Ministry of Education, Taiwan, R.O.C.
- noncovalent interactions;
- supramolecular chemistry
A new system for the incorporation of a phenyl/perfluorophenyl pair in the structure of a peptide hydrogelator was developed. The strategy is based on the idea that the integration of an end-capped perfluorophenyl group and a phenylalanine with a phenyl moiety in the side chain forms an intramolecular phenyl/perfluorophenyl pair, which can be used to promote the formation of the supramolecular nanofibers and hydrogels. This work illustrates the importance of structure-hydrogelation relationship and provides new insights into the design of self-assembly nanobiomaterials.