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Intramolecular Interactions of a Phenyl/Perfluorophenyl Pair in the Formation of Supramolecular Nanofibers and Hydrogels

Authors

  • Shu-Min Hsu,

    1. Department of Materials Science and Engineering, National Chiao Tung University, Hsinchu, 300, Taiwan (Republic of China)
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  • Yu-Chun Lin,

    1. Department of Materials Science and Engineering, National Chiao Tung University, Hsinchu, 300, Taiwan (Republic of China)
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  • Jui-Wen Chang,

    1. Department of Materials Science and Engineering, National Chiao Tung University, Hsinchu, 300, Taiwan (Republic of China)
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  • Yu-Hao Liu,

    1. Department of Materials Science and Engineering, National Chiao Tung University, Hsinchu, 300, Taiwan (Republic of China)
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  • Prof. Dr. Hsin-Chieh Lin

    Corresponding author
    1. Department of Materials Science and Engineering, National Chiao Tung University, Hsinchu, 300, Taiwan (Republic of China)
    • Department of Materials Science and Engineering, National Chiao Tung University, Hsinchu, 300, Taiwan (Republic of China)

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  • We thank Prof. Shiaw-Guang Hu for technical support. We also thank the National Science Council of the Republic of China, Taiwan (Grant No. NSC 100-2113M-009-015-MY2) and the “Aim for the Top University” program of the National Chiao Tung University and Ministry of Education, Taiwan, R.O.C. for funding. We are also grateful to the National Center for High-performance Computing of Taiwan for computer time and facilities.

Abstract

A new system for the incorporation of a phenyl/perfluorophenyl pair in the structure of a peptide hydrogelator was developed. The strategy is based on the idea that the integration of an end-capped perfluorophenyl group and a phenylalanine with a phenyl moiety in the side chain forms an intramolecular phenyl/perfluorophenyl pair, which can be used to promote the formation of the supramolecular nanofibers and hydrogels. This work illustrates the importance of structure-hydrogelation relationship and provides new insights into the design of self-assembly nanobiomaterials.

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