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Regulating Angiogenesis with Light-Inducible AntimiRs

Authors

  • Florian Schäfer,

    1. Institute for Organic Chemistry and Chemical Biology, Buchmann Institute for Molecular Life Sciences, Goethe-University Frankfurt, Max-von-Laue-Strasse 9, 60438 Frankfurt (Germany)
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    • These authors have contributed equally to this work.

  • Dr. Jasmin Wagner,

    1. Institute of Cardiovascular Regeneration, Centre for Molecular Medicine, Goethe-University Frankfurt, Theodor-Stern-Kai 7, 60590 Frankfurt (Germany)
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    • These authors have contributed equally to this work.

  • Andrea Knau,

    1. Institute of Cardiovascular Regeneration, Centre for Molecular Medicine, Goethe-University Frankfurt, Theodor-Stern-Kai 7, 60590 Frankfurt (Germany)
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  • Prof. Dr. Stefanie Dimmeler,

    Corresponding author
    1. Institute of Cardiovascular Regeneration, Centre for Molecular Medicine, Goethe-University Frankfurt, Theodor-Stern-Kai 7, 60590 Frankfurt (Germany)
    • Stefanie Dimmeler, Institute of Cardiovascular Regeneration, Centre for Molecular Medicine, Goethe-University Frankfurt, Theodor-Stern-Kai 7, 60590 Frankfurt (Germany)

      Alexander Heckel, Institute for Organic Chemistry and Chemical Biology, Buchmann Institute for Molecular Life Sciences, Goethe-University Frankfurt, Max-von-Laue-Strasse 9, 60438 Frankfurt (Germany)

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  • Prof. Dr. Alexander Heckel

    Corresponding author
    1. Institute for Organic Chemistry and Chemical Biology, Buchmann Institute for Molecular Life Sciences, Goethe-University Frankfurt, Max-von-Laue-Strasse 9, 60438 Frankfurt (Germany)
    • Stefanie Dimmeler, Institute of Cardiovascular Regeneration, Centre for Molecular Medicine, Goethe-University Frankfurt, Theodor-Stern-Kai 7, 60590 Frankfurt (Germany)

      Alexander Heckel, Institute for Organic Chemistry and Chemical Biology, Buchmann Institute for Molecular Life Sciences, Goethe-University Frankfurt, Max-von-Laue-Strasse 9, 60438 Frankfurt (Germany)

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  • We thank the Deutsche Forschungsgemeinschaft (DFG) for financial support through SFB 902 “Molecular Principles of RNA-Based Regulation”.

Abstract

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The inhibition of microRNAs (miRs) in a spatiotemporally defined manner by an exogenous trigger would help to specifically target the biological activity and avoid off-target effects. Novel antimiRs directed against miR-92a can be activated by irradiation (see scheme; 3′-UTR=3′-untranslated region) In this way miR-92a is inhibited, the miR-92a target integrin α5 is derepressed, and angiogenesis of endothelial cells is enhanced.

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