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Keywords:

  • nucleic acid analogues;
  • RNA polymerase II;
  • sugar integrity;
  • synthetic biology;
  • transcriptional fidelity
Thumbnail image of graphical abstract

Transcription unlocked: A synthetic chemical biology approach involving unlocked nucleic acids was used to dissect the contribution of sugar backbone integrity to the RNA Polymerase II (Pol II) transcription process. An unexpected dominant role for sugar-ring integrity in Pol II transcriptional efficiency and fidelity was revealed.