This study was financially supported in part by Kakenhi (25288045, 24105513, Project No. 2304: Advanced Molecular Transformation by Organocatalysts) and JST (ACT-C).
Kinetic Resolution of Allyl Fluorides by Enantioselective Allylic Trifluoromethylation Based on Silicon-Assisted CF Bond Cleavage†
Article first published online: 7 NOV 2013
Copyright © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 53, Issue 2, pages 517–520, January 7, 2014
How to Cite
Nishimine, T., Fukushi, K., Shibata, N., Taira, H., Tokunaga, E., Yamano, A., Shiro, M. and Shibata, N. (2014), Kinetic Resolution of Allyl Fluorides by Enantioselective Allylic Trifluoromethylation Based on Silicon-Assisted CF Bond Cleavage. Angew. Chem. Int. Ed., 53: 517–520. doi: 10.1002/anie.201308071
- Issue published online: 2 JAN 2014
- Article first published online: 7 NOV 2013
- Manuscript Received: 14 SEP 2013
- Kakenhi. Grant Numbers: 25288045, 24105513
- allyl fluorides;
- kinetic resolution;
Two birds, one stone! The first kinetic resolution of allyl fluorides was achieved by the development of an organocatalyzed enantioselective allylic trifluoromethylation. Two kinds of chiral fluorinated compounds, which incorporate C*F and C*CF3 units, respectively, can thus be accessed by a single transformation.