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Kinetic Resolution of Allyl Fluorides by Enantioselective Allylic Trifluoromethylation Based on Silicon-Assisted C[BOND]F Bond Cleavage


  • This study was financially supported in part by Kakenhi (25288045, 24105513, Project No. 2304: Advanced Molecular Transformation by Organocatalysts) and JST (ACT-C).


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Two birds, one stone! The first kinetic resolution of allyl fluorides was achieved by the development of an organocatalyzed enantioselective allylic trifluoromethylation. Two kinds of chiral fluorinated compounds, which incorporate C*[BOND]F and C*[BOND]CF3 units, respectively, can thus be accessed by a single transformation.

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