Cover Picture: On the Way Towards Greener Transition-Metal-Catalyzed Processes as Quantified by E Factors (Angew. Chem. Int. Ed. 42/2013)



original image

As E Factors drop it's a win-win for chemistry and the environment. In their Minireview on page 10952 ff., B. H. Lipshutz and co-workers document, by direct comparisons with transition-metal-catalyzed cross-coupling reactions from pharma, just how low they can go using a commercially available designer surfactant in water as the reaction medium. As the organic solvent usage drops, E Factors can plummet by as much as an order of magnitude. Let's get organic solvents out of organic reactions, and increase sustainability.