Inside Cover: Chemoselective Oxidative C(CO)[BOND]C(methyl) Bond Cleavage of Methyl Ketones to Aldehydes Catalyzed by CuI with Molecular Oxygen (Angew. Chem. Int. Ed. 43/2013)



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The selective oxidative cleavage of C[BOND]C σ-bonds is a great challenge in chemistry and biology. In their Communication on page 11303 ff., X. Bi, Q. Liu, and co-workers describe a novel method for the oxidative C(CO)[BOND]C(α) bond cleavage of ketones that completely terminates at the aldehyde stage. A wide range of aromatic and aliphatic methyl ketones could be transformed into aldehydes with a copper catalyst under an oxygen atmosphere, along with the release of H2 and CO2 as the by-products.