These authors contributed equally to this work.
Cover Picture: Binding of a Designed Anti-Cancer Drug to the Central Cavity of an RNA Three-Way Junction (Angew. Chem. Int. Ed. 44/2013)
Article first published online: 2 OCT 2013
Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 52, Issue 44, page 11427, October 25, 2013
How to Cite
Phongtongpasuk, S., Paulus, S., Schnabl, J., Sigel, R. K. O., Spingler, B., Hannon, M. J. and Freisinger, E. (2013), Cover Picture: Binding of a Designed Anti-Cancer Drug to the Central Cavity of an RNA Three-Way Junction (Angew. Chem. Int. Ed. 44/2013). Angew. Chem. Int. Ed., 52: 11427. doi: 10.1002/anie.201308234
- Issue published online: 21 OCT 2013
- Article first published online: 2 OCT 2013
- antitumor agents;
- bioinorganic chemistry;
- RNA recognition;
- three-way junctions
Recognition and stabilization of an RNA three-way junction by a supramolecular di-iron(II) cylindrical complex is described by R. K. O. Sigel, B. Spingler, M. J. Hannon, E. Freisinger et al. in their Communication on page 11513 ff. This potential anti-cancer metal-based drug fits perfectly into the central RNA core and stabilizes this architecture in the solid state as well as under native gel conditions. (Cover picture: Joachim Schnabl.)
AFM shows that amphiphilic pyrene trimers self-assemble into 2D, supramolecular sheet-like structures. R. Häner and co-workers report in their Communication on page 11488 ff. that the fluorescence properties of these structures are significantly changed by the self-assembly process.
T. Friščić and co-workers describe in their Communication on page 11538 ff. how ball-milling reactions of organic pharmaceutical solids can be monitored in situ and in real time with high-energy X-rays.
α5β1 or αvβ3 subtype-selective integrin antagonists can be functionalized with NODAGA. In their Communication on page 11656 ff., H. Kessler and co-workers show these peptidomimetics make in vivo tumor imaging possible by positron emission tomography (PET).