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Keywords:

  • antitumor agents;
  • bioinorganic chemistry;
  • helicates;
  • RNA recognition;
  • three-way junctions

Recognition and stabilization of an RNA three-way junction by a supramolecular di-iron(II) cylindrical complex is described by R. K. O. Sigel, B. Spingler, M. J. Hannon, E. Freisinger et al. in their Communication on page 11513 ff. This potential anti-cancer metal-based drug fits perfectly into the central RNA core and stabilizes this architecture in the solid state as well as under native gel conditions. (Cover picture: Joachim Schnabl.)

Supramolecular Polymers

AFM shows that amphiphilic pyrene trimers self-assemble into 2D, supramolecular sheet-like structures. R. Häner and co-workers report in their Communication on page 11488 ff. that the fluorescence properties of these structures are significantly changed by the self-assembly process.

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Mechanochemistry

T. Friščić and co-workers describe in their Communication on page 11538 ff. how ball-milling reactions of organic pharmaceutical solids can be monitored in situ and in real time with high-energy X-rays.

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Tumor Imaging

α5β1 or αvβ3 subtype-selective integrin antagonists can be functionalized with NODAGA. In their Communication on page 11656 ff., H. Kessler and co-workers show these peptidomimetics make in vivo tumor imaging possible by positron emission tomography (PET).

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