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Synthesis of 6-Alkylated Phenanthridine Derivatives Using Photoredox Neutral Somophilic Isocyanide Insertion


  • Financial support from the National Basic Research Program of China (2011CB935800), the 863 program (2013AA092903), the National Natural Science Foundation of China (21121091, 21102072), and the Natural Science Foundation of Jiangsu Province (BK2012012, BK20131266) is acknowledged. We thank Prof. Li-Zhu Wu and Qing-Yuan Meng for helping with the determination of the quantum yield.


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Bring to light: The first visible-light-promoted somophilic isocyanide insertion occurs using an iridium photocatalyst. This efficient synthetic approach provides a rapid entry to 6-alkylated phenanthridine derivatives (see scheme). The reactions proceed at room temperature in good to excellent yields with broad substrate scope and under environmentally friendly conditions.

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