Cover Picture: Lipid-Bilayer-Spanning DNA Nanopores with a Bifunctional Porphyrin Anchor (Angew. Chem. Int. Ed. 46/2013)



original image

Membrane nanopores self-assembled from DNA are the most recent type of synthetic channels. Inserting negatively charged DNA origami structures into a hydrophobic membrane can be achieved with just two porphyrin-based lipid anchors, as shown by S. Howorka and co-workers in their Communication on page 12069 ff. Minimal chemical intervention paves the way to new DNA pores for label-free biosensing and research into single molecules and biomimetic nanoarchitectures. (Simplified illustration of origami pores by Silvio Bianco, Hugh Martin, Jonathan R. Burns.)