Ruthenium-Catalyzed Cross-Dehydrogenative ortho-N-Carbazolation of Diarylamines: Versatile Access to Unsymmetrical Diamines


  • This work was supported by the DFG-funded transregional collaborative research center SFB/TRR 88 “Cooperative effects in homo- and heterometallic complexes (”. Corinna Nimphius is also acknowledged.


The dehydrogenative C–N cross-coupling of unprotected, secondary anilines through ortho-N-carbazolation has been achieved using a Ru catalytic system with O2 as the terminal oxidant. The reactions proceed in an intermolecular fashion, selectively in the ortho position. Implications for the field of organic synthesis are discussed.