Dirhodium(II) Carboxylate Catalyzed Formation of 1,2,3-Trisubstituted Indoles from Styryl Azides


  • We are grateful to the National Institutes of Health NIGMS (R01GM984945) and the University of Illinois at Chicago for their generous support.


Dirhodium(II)-carboxylate complexes were discovered to promote the selective migration of acyl groups in trisubstituted styryl azides to form 1,2,3-trisubstituted indoles. The styryl azides are readily available in three steps from cyclobutanone and 2-iodoaniline.