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Keywords:

  • drug delivery;
  • macromolecular carrier systems;
  • polyglycerols;
  • polyphenols;
  • self-assembly
Thumbnail image of graphical abstract

Release on demand: The pH gradients between extra- and intracellular regions can be utilized for the controlled release of drugs and biological cargos from delivery systems. Biocompatible carrier systems with pH-cleavable units must fulfill many other criteria as well, for example, a long blood circulation time. This can be achieved by tailored micro- and nanocarriers based on macromolecular architectures or stable self-assembled systems.