We thank the SFB 1112 of the German Research Foundation and the Helmholtz Virtual Institute for funding.
pH-Responsive Micro- and Nanocarrier Systems†
Article first published online: 4 DEC 2013
Copyright © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 53, Issue 1, pages 49–51, January 3, 2014
How to Cite
Nowag, S. and Haag, R. (2014), pH-Responsive Micro- and Nanocarrier Systems. Angew. Chem. Int. Ed., 53: 49–51. doi: 10.1002/anie.201308619
- Issue published online: 23 DEC 2013
- Article first published online: 4 DEC 2013
- Manuscript Received: 3 OCT 2013
- German Research Foundation
- drug delivery;
- macromolecular carrier systems;
Release on demand: The pH gradients between extra- and intracellular regions can be utilized for the controlled release of drugs and biological cargos from delivery systems. Biocompatible carrier systems with pH-cleavable units must fulfill many other criteria as well, for example, a long blood circulation time. This can be achieved by tailored micro- and nanocarriers based on macromolecular architectures or stable self-assembled systems.