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Tunable Visible and Near-IR Photoactivation of Light-Responsive Compounds by Using Fluorophores as Light-Capturing Antennas

Authors

  • Prof. Thomas A. Shell,

    Corresponding author
    1. Department of Chemistry, Division of Chemical Biology and Medicinal Chemistry, and the Department of Pharmacology, University of North Carolina,Chapel Hill, NC 27599 (USA)
    • Department of Chemistry, Division of Chemical Biology and Medicinal Chemistry, and the Department of Pharmacology, University of North Carolina,Chapel Hill, NC 27599 (USA)

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  • Prof. Jennifer R. Shell,

    1. Department of Chemistry, Division of Chemical Biology and Medicinal Chemistry, and the Department of Pharmacology, University of North Carolina,Chapel Hill, NC 27599 (USA)
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  • Zachary L. Rodgers,

    1. Department of Chemistry, Division of Chemical Biology and Medicinal Chemistry, and the Department of Pharmacology, University of North Carolina,Chapel Hill, NC 27599 (USA)
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  • Prof. David S. Lawrence

    Corresponding author
    1. Department of Chemistry, Division of Chemical Biology and Medicinal Chemistry, and the Department of Pharmacology, University of North Carolina,Chapel Hill, NC 27599 (USA)
    • Department of Chemistry, Division of Chemical Biology and Medicinal Chemistry, and the Department of Pharmacology, University of North Carolina,Chapel Hill, NC 27599 (USA)

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  • We thank the National Institutes of Health for financial support (RO1 CA79954).

Abstract

Although the corrin ring of vitamin B12 is unable to efficiently absorb light beyond 550 nm, it is shown that commercially available fluorophores can be used as antennas to capture long-wavelength light to promote scission of the Co[BOND]C bond at wavelengths up to 800 nm. The ability to control the molecular properties of bioactive species with long visible and near-IR light has implications for drug delivery, nanotechnology, and the spatiotemporal control of cellular behavior.

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